There have been cases of certain kinds of cancer, in patients taking medications or other blockers.  Patients with RA, especially more serious RA, may have a higher chance of getting a kind of cancer called lymphoma.  Some patients receiving treatment of medicines have developed types of cancer called non-melanoma skin cancer, which are generally not life threatening if treated.  Tell your doctor if you have a bump or open sore that does not heal.  Allergic reactions, signs of a serious allergic reaction include rash, a swollen face, or trouble breathing.  Hepatitis B virus reactivation in patients that carry the virus in their blood.  Tell your doctor if you have any of the following symptoms: feel unwell, poor appetite, fatigue, fever, rash or joint pain.